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    芝麻油對抗Acetaminophen誘發之急性肝臟傷害之影響.pdf檔名:1426002676890.pdf
    篇名/題名:Effects of Sesame Oil Against After the Onset of Acetaminophen-Induced Acute Hepatic Injury in Rats
    並列篇名:芝麻油對抗Acetaminophen誘發之急性肝臟傷害之影響
    摘要:Acetaminophen (APAP) is a safe and effective analgesic and antipyretic when used at therapeutic levels. However,an acute or cumulative overdose can cause severe liver injury with the potential to progress to liver failure in humans and experimental
    animals. Much attention has been paid to the development of an antioxidant that protects against APAP-induced acute hepatic injury. Hence, we aimed to investigate the effect of sesame oil against after the onset of acute hepatic injury in APAPoverdosed rats. Methods: Male Wistar rats were first given 2 oral doses (1,000 mg/kg each) of APAP (at 0 and 24 hours) and then 1 oral dose of sesame oil (8 mL/kg at 24 hours). Results: After 48
    hours, APAP increased aspartate and alanine aminotransferase levels in the rats ’ serum and centrilobular necrosis in liver tissue.
    In addition, APAP significantly decreased the rats’ glutathione levels and mitochondrial aconitase activity, but increased superoxide anion, hydroxyl radical, and lipid peroxidation levels. Oral
    sesame oil (8 mL/kg, given at 24 hours) reversed all APAP-altered parameters and protected the rats against APAP-induced acute
    liver injury. Conclusion: We hypothesize that sesame oil acts as a useful agent that maintains intracellular glutathione levels and inhibits reactive oxygen species, thereby protecting rats against after the onset of APAP-induced acute oxidative liver injury. (JPEN J Parenter Enteral Nutr. 2010;34:567-573)
    類型:期刊論文
    西元出版年:2010
    著作語言:en_US
    關鍵詞:acetaminophenglutathioneaconitasereactive oxygen speciessesame oil
    作者:Se-Ping Chien、簡思平
    學校系所:餐飲系