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    尿激纖~1.PDF檔名:1426002669137.PDF
    篇名/題名:Evaluation of the Association of Urokinase Plasminogen Activator
    摘要:Background. The urokinase plasminogen activator (uPA)
    system is a serine proteinase system involved in extracellular
    matrix (ECM) degradation. The levels of uPA system components
    in tumor tissues are implicated as prognostic
    biomarkers in a wide range of malignancies. Although the
    contributions of uPA system components to the formation of
    many types of cancer are well known, their possible association
    with the prediction of risk and prognosis of hepatocellular
    carcinoma (HCC) remains poorly investigated.
    Methods. A total of 102 HCC patients and 344 controls
    were recruited. Genetic polymorphisms of uPA system
    genes, including uPA, uPA receptor (uPAR), and plasminogen
    activator inhibitor (PAI)-1, were analyzed by
    polymerase chain reaction-restriction fragment length
    polymorphism (PCR-RFLP) genotyping analysis.
    Results. When individuals were classified into male and
    female subgroups to estimate adjusted odds ratios (AORs)with their 95% confidence intervals (CIs) of each uPAsystem gene, the HCC risks of males and females with PAI-1
    類型:期刊論文
    西元出版年:2010
    著作語言:en_US
    作者:翁家瑞、Chia-Jui Weng
    學校系所:生活應用科學碩士班