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    11-翁家瑞(Survivin T9809C, an SNP Located in 30-UTR).pdf檔名:1445590212646.pdf
    篇名/題名:Survivin T9809C, an SNP Located in 30-UTR, Displays a Correlation with the Risk and Clinicopathological Development of Hepatocellular Carcinoma
    摘要:Background. Early detection of hepatocellular carcinoma
    (HCC) is seldom available because of the lack of reliable
    markers. Survivin is an anti-apoptotic protein that is implicated
    in the regulation of apoptosis and cell cycle, and it is
    undetectable in normal adult tissues but is overexpressed in
    various types of cancers. Survivin is thus commonly considered
    to be a marker of malignancy. The aim of this study
    was to explore the association between survivin gene polymorphisms
    and the risk and diagnostic progress of HCC.
    Methods. A total of 135 patients with HCC and 496
    healthy control subjects were recruited. Five single nucleotide
    polymorphisms (SNPs) of survivin genes were
    determined by real-time polymerase chain reaction (realtime
    PCR) and further analyzed statistically.
    Results. We first found that the -241 C/T and -235 G/A
    genetic polymorphisms of survivin did not occur frequently
    enough or even lacked in Taiwanese population. The
    ?9809 C/C polymorphism exhibited a significant (P.05)
    low risk of 0.525-fold (95% confidence interval [95% CI] =
    0.297–0.930) to have HCC compared with the wild-type
    homozygotes and a low ratio of 0.214-fold (95%
    CI = 0.051–0.890) for positive anti-HCV was shown in
    the individuals with survivin ?9809 polymorphic CC allele
    compared with the TT/TC genotypic subgroup.
    Conclusions. Survivin ?9809 polymorphic genotype is
    associated with the risk of HCC, and the HCC patients with
    survivin ?9809 CC homozygotes might have a low risk of
    developing infected HCV-dependent HCC. The results
    suggest that the survivin T9809C SNP might contribute to
    the prediction of susceptibility and pathological development
    to HCC.
    類型:期刊論文
    西元出版年:2012
    著作語言:英文
    作者:作者:
     翁家瑞(Chia-Jui Weng,)
    學校系所:生活應用科學碩士班
    卷期:Annals of Surgical Oncology;period 19 期
    頁碼:S625–S633