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    10-翁家瑞(Single Nucleotide Polymorphisms and Haplotypes of MMP.pdf檔名:1445589957445.pdf
    篇名/題名:Single Nucleotide Polymorphisms and Haplotypes of MMP-14 are Associated with the Risk and Pathological Development of Oral Cancer
    摘要:Background. Matrix metalloproteinase (MMP)-14 is one
    of the pericellular collagenases to degrade extracellular
    matrix (ECM), which is involved to the modulation of
    susceptibility or clinicopathological features of a cancer.
    The contributions of MMP-14 on the susceptibility or
    clinicopathological features of certain cancers have been
    well documented, and the expression of MMP-14 in oral
    squamous cell carcinoma (OSCC) also has been observed.
    This study was designed to examine the association of
    MMP-14 gene polymorphisms with the susceptibility and
    clinicopathological development of OSCC.
    Methods. A total of 363 patients with OSCC and 506
    healthy control subjects were recruited. Six single nucleotide
    polymorphisms (SNPs) of MMP-14 genes were
    analyzed by polymerase chain reaction-restriction fragment
    length polymorphism genotyping and haplotype-base
    analysis.
    Results. MMP-14 ?7096 TC/CC genotypes might lower
    the risk of OSCC, and MMP-14 ?6767 GA/AA genotypes
    cause a poor clinical status in OSCC patients. The ?6727
    C: ?6767 G: ?7096 T: ?8153 G haplotype and diplotype
    increased the risk for OSCC by 1.706-fold (95% confidence
    interval (CI) 1.383–2.105) and 2.276-fold (95%
    CI = 1.531–3.384), respectively, compared with the reference.
    The diplotype with at least one CGTG exhibited a
    high risk (adjusted odds ratio, 1.639; 95% CI, 1.005–2.673)
    for developing a poor clinicopathological diagnosis of
    OSCC compared with the others/other diplotype.
    Conclusions. The ?7096 and ?6767 polymorphic genotypes
    and haplotype ?6727 C: ?6767 G: ?7096 T: ?8153
    G of MMP-14 gene might contribute to the prediction of
    susceptibility and pathological development of OSCC.
    類型:期刊論文
    西元出版年:2012
    著作語言:英文
    作者:作者:
     翁家瑞(Chia-Jui Weng)
    學校系所:生活應用科學碩士班
    卷期:Annals of Surgical Oncology;period 19 期
    頁碼:S319–S327