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    7-翁家瑞(Assessment of the Anti-invasion Potential and Mechanis.pdf檔名:1445587776514.pdf
    篇名/題名:Assessment of the Anti-invasion Potential and Mechanism of Select Cinnamic Acid Derivatives on Human Lung Adenocarcinoma Cells
    摘要:Patients with lung adenocarcinoma are often
    diagnosed with metastasizing symptoms and die of early and
    distal metastasis. Metastasis is made up of a cascade of
    interrelated and sequential steps, including cell adhesion,
    extracellular matrix degradation, cell movement, and invasion.
    Hence, substances carrying the ability to stop one of the
    metastasis-associated steps could be a potential candidate for
    preventing tumor cells from metastasizing and prolonging the
    life of cancer patients. Cinnamic acid (CA) was demonstrated
    to be such a candidate for human lung adenocarcinoma cells.
    Nevertheless, the effectiveness of CA derivatives on invasion of
    lung cancer cells is still unclear. The aims of this study were to
    explore the mechanisms underlying several select CA
    derivatives against invasion of human lung adenocarcinoma A549 cells. The results revealed that caffeic acid (CAA),
    chlorogenic acid (CHA), and ferulic acid (FA) can inhibit phorbol-12-myristate-13-acetate (PMA)-stimulated invasion of A549
    cells at a concentration of ≥100 μM. The MMP-9 activity was suppressed by these compounds through regulating urokinase-type
    plasminogen activator (uPA), tissue inhibitor of metalloproteinase (TIMP)-1, plasminogen activator inhibitor (PAI)-1, and
    PAI-2; the cell-matrix adhesion was decreased by CAA only. The proposed molecular mechanism involved not only decreasing
    the signaling of MAPK and PI3K/Akt but also inactivating NF-κB, AP-1, and STAT3. In the present study, we selected CAA,
    CHA, and FA as potential inhibitors for invasive behaviors of human lung adenocarcinoma cells and disclosed the possible
    mechanisms. The association between structural features and anti-invasive activity of these compounds cannot be determined
    here and needs to be further verified
    類型:期刊論文
    西元出版年:2013
    著作語言:英文
    關鍵詞:caffeic acidchlorogenic acidcinnamic acid derivativesferulic acidinvasionlung adenocarcinoma cells
    作者:作者:
     翁家瑞(Chia-Jui Weng)
    學校系所:生活應用科學碩士班
    卷期:Molecular Pharmaceutics;period 10 期
    頁碼:1890-1900