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    Survivin SNP-carcinogen Interactions in Oral Cancer-翁家瑞.pdf
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    Survivin SNP-carcinogen Interactions in Oral Cancer-翁家瑞.pdf檔名:1426002663162.pdf
    篇名/題名:Survivin SNP-carcinogen Interactions in Oral Cancer
    摘要:In Taiwan, oral cancer is causally associated with environmental protein and
    is generally considered a marker of malignancy. The current study explored the combined effect of survivin gene polymorphisms and environmental carcinogens on the risk and clinico-pathological development of oral cancer. Five singlenucleotide polymorphisms (SNPs) of survivin genes from 439 male patients with oral cancer and 424 male control
    participants (who did not have cancer) were analyzed. The survivin -31GG, +9194 GG, and +9809 TT homozygotes exhibited higher risk for oral cancer compared with the corresponding
    ancestral genotype, after adjustment for related confounders. The survivin -31, +9194, and +9809 SNPs combined with betel quid chewing and/or tobacco consumption
    could robustly elevate susceptibility to oral cancer. The distribution frequency of the -31 G: +9194 A: +9809 T haplotype
    was significantly higher in oral cancer patients than in control participants. These results suggest that survivin gene
    polymorphisms and their interactions with environmental carcinogens may increase susceptibility to oral cancer in Taiwanese men.
    類型:期刊論文
    西元出版年:2012
    著作語言:en_US
    關鍵詞:Survivinenvironmental carcinogenhaplotypehaplotype, betel quid.single-nucleotide polymorphismoral squamous cell carcinoma
    作者:C.J. Weng、Y.H. Hsieh、M.K. Chen、C.M. Tsai、C.W. Lin、S.F. Yang
    學校系所:生活應用科學碩士班